Organ-specific inflammation following acute ethanol and burn injury
نویسندگان
چکیده
منابع مشابه
Distant organ injury following acute kidney injury.
ACUTE KIDNEY INJURY (AKI) is associated with unacceptably high mortality that can range from 40 to 60% in some cases (14). The incidence of AKI continues to increase (15, 16) and is associated with a changing spectrum of illnesses, significant comorbid and extrarenal complications (12), and unsatisfactory preventive or treatment strategies (5). The etiology of AKI is diverse, and ischemia const...
متن کاملSystemic inflammation and remote organ injury following trauma require HMGB1.
High-mobility group box 1 (HMGB1) is a 30-kDa DNA-binding protein that displays proinflammatory cytokine-like properties. HMGB1-dependent inflammatory processes have been demonstrated in models of sterile injury, including ischemia-reperfusion injury and hemorrhagic shock. Here, we tested the hypothesis that the systemic inflammatory response and associated remote organ injury that occur after ...
متن کاملAcute burn injury.
Almost 2 million people in the United States suffer from burns annually. A small percentage of these injuries are fatal, but all require some degree of medical attention. Burn injury is associated with anatomic, physiologic, endocrinologic, and immunologic alterations. These problems need to be identified and treated properly to prevent or minimize the extent of the damage. In recent years, adv...
متن کاملLong-term remote organ consequences following acute kidney injury.
Acute kidney injury (AKI) has been a global health epidemic problem with soaring incidence, increased long-term risks for multiple comorbidities and mortality, as well as elevated medical costs. Despite the improvement of patient outcomes following the advancements in preventive and therapeutic strategies, the mortality rates among critically ill patients with AKI remain as high as 40-60 %. The...
متن کاملAcute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats.
In this study, we examined whether IL-18 plays a role in lung inflammation following alcohol (EtOH) and burn injury. Male rats ( approximately 250 g) were gavaged with EtOH to achieve a blood EtOH level of approximately 100 mg/dl before burn or sham injury ( approximately 12.5% total body surface area). Immediately after injury, rats were treated with vehicle, caspase-1 inhibitor AC-YVAD-CHO to...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2008
ISSN: 0741-5400
DOI: 10.1189/jlb.1107766